Publications by authors named "P J Collier"
The tumour microenvironment (TME) significantly influences tumour formation and progression through dynamic interactions. Cholangiocarcinoma (CCA), a highly desmoplastic tumour, lacks early diagnostic biomarkers and has limited effective treatments owing to incomplete understanding of its molecular pathogenesis. Investigating the role of the TME in CCA progression could lead to better therapies.
View Article and Find Full Text PDFAims: Immune checkpoint inhibitors (ICI) are the cornerstone of modern oncology; however, side effects such as ICI-related myocarditis (irM) can be fatal. Recently, Bonaca proposed criteria for irM; however, it is unknown if they correlate well with cardiovascular (CV) ICI-related adverse events. Additionally, whether incident irM portends worse long-term CV outcomes remains unclear.
View Article and Find Full Text PDFThe early detection of transthyretin cardiac amyloidosis (ATTR-CM) is essential, with Tc-99m pyrophosphate scintigraphy (PYP scan) being a key diagnostic tool. Although a previously validated score has shown promise in predicting PYP scan positivity among patients with HFpEF, further evaluation in diverse cohorts is necessary. To assess the effectiveness of the ATTR-CM score in predicting PYP scan positivity within our patient population.
View Article and Find Full Text PDFArticle Synopsis
- - The study analyzed cardiovascular outcomes related to uric acid-lowering medications, finding no significant benefits for xanthine oxidase inhibitors (XOI) compared to placebo in terms of major cardiovascular events.
- - The meta-analysis included 47 studies with over 3.8 million patients, showing that while there was no substantial difference in cardiovascular risks with XOI, Febuxostat may lower the risk of heart failure compared to Allopurinol.
- - The researchers concluded that further studies are needed to confirm these findings, particularly the potential heart failure benefits of Febuxostat and the overall ineffectiveness of XOI in reducing cardiovascular events.
Aims: Dynamic alterations in cardiac DNA methylation have been implicated in the development of heart failure (HF) with evidence of ischaemic heart disease (IHD); however, there is limited research into cell specific, DNA methylation sensitive genes that are affected by dysregulated DNA methylation patterns. In this study, we aimed to identify DNA methylation sensitive genes in the ischaemic heart and elucidate their role in cardiac fibrosis.
Methods: A multi-omics integrative analysis was carried out on RNA sequencing and methylation sequencing on HF with IHD (n = 9) versus non-failing (n = 9) left ventricular tissue, which identified Integrin beta-like 1 (ITGBL1) as a gene of interest.