Publications by authors named "P J Chowienczyk"
Article Synopsis
- Pulmonary embolism (PE) is a serious complication of COVID-19 that can lead to chronic thromboembolic pulmonary disease (CTEPD) and chronic thromboembolic pulmonary hypertension (CTEPH), but the true burden and best screening methods for these conditions are still not clear.
- During the study from 2017 to 2022, only a small percentage of CTEPH cases were linked to previous COVID-19 infections, with the CTEPH rates returning to pre-pandemic levels after the second year of the pandemic.
- The findings suggest that while the risk of developing CTEPH after hospitalization for COVID-19 is low, using simple clinical risk scores can help identify patients who may need further evaluation.
Objectives: Effects of potassium supplementation on blood pressure (BP) may be offset by an increase in plasma aldosterone. The magnitude of potassium-dependent regulation of aldosterone secretion in humans is not fully characterized; it is not clear whether this is mediated by activation of the renin-angiotensin-aldosterone system (RAAS), as a result of a reduction in BP or other mechanisms. We performed a systematic review and meta-analysis of clinical trials assessing effects of potassium on plasma aldosterone and renin in adult individuals.
View Article and Find Full Text PDFBackground: Increased arterial stiffness and pulse wave velocity (PWV) of the aorta and large arteries impose adverse hemodynamic effects on the heart and other organs. Antihypertensive treatment reduces PWV, but it is unknown whether this results from an unloading of stiffer elements in the arterial wall or is due to an alternate functional or structural change that might differ according to class of antihypertensive drug.
Methods: We performed a systematic review and meta-analysis of the effects of different antihypertensive drug classes and duration of treatment on PWV with and without adjustment for change in mean arterial blood pressure (BP; study 1) and compared this to the change in PWV after an acute change in transmural pressure, simulating an acute change in BP (study 2).
Introduction: Aortic root dilatation is a reported cardiovascular sequela seen in children and young people (CYP) with chronic kidney disease (CKD) but has yet to be described in those with autosomal dominant polycystic kidney disease (ADPKD).
Methods: Single center, cross-sectional study in a dedicated ADPKD clinic. Echocardiograms were evaluated for the presence of dilatation (defined by a z-score ≥2 [≥99th percentile] SDs from the mean) at 4 standardized locations, namely the aortic valve annulus, sinuses of Valsalva (SoV), sinotubular junction (STJ), and the ascending aorta.
Article Synopsis
- Scientists studied how to predict and catch heart failure early using blood tests that check for certain substances called metabolites.
- They looked at data from over 68,000 people over about 12 years to see if these metabolites could help identify who might get heart failure.
- They found that adding these metabolite tests to traditional methods made it better at predicting heart problems, meaning they can help doctors keep people healthier.