Publications by authors named "P J Brantley"
Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.
Phys Rev Lett
February 2024
Article Synopsis
- * This experiment produced 2.05 MJ of laser energy, resulting in 3.1 MJ of total fusion yield, which exceeds the Lawson criterion for ignition, demonstrating a key milestone in fusion research.
- * The report details the advancements in target design, laser technology, and experimental methods that contributed to this historic achievement, validating over five decades of research in laboratory fusion.
It is well recognized that patients with severe obesity exhibit remarkable heterogeneity in response to different types of weight-loss interventions. Those who undergo Roux-en-Y gastric bypass (RYGB) usually exhibit more favorable glycemic outcomes than those who receive adjustable gastric banding (BAND) or intensive medical intervention (IMI). The molecular mechanisms behind these observations, however, remain largely unknown.
View Article and Find Full Text PDFPredictors of racial differences in weight loss: the PROPEL trial.
Obesity (Silver Spring)
March 2024
Objective: Studies have consistently shown that African American individuals lose less weight in response to behavioral interventions, but the mechanisms leading to this result have been understudied.
Methods: Data were derived from the PROmoting Successful Weight Loss in Primary CarE in Louisiana (PROPEL) study, which was a cluster-randomized, two-arm trial conducted in primary care clinics. In the PROPEL trial, African American individuals lost less weight compared with patients who belonged to other racial groups after 24 months.
Background: Alterations in DNA methylation (DNAm) have been reported to be a mechanism by which bariatric surgeries resulted in considerable metabolic improvements. Previous studies have mostly focused on change in DNAm following weight-loss interventions, yet whether DNAm prior to intervention can explain the variability in glycemic outcomes has not been investigated. Here, we aim to examine whether baseline DNAm is differentially associated with glycemic outcomes induced by different types of weight-loss interventions.
View Article and Find Full Text PDFArticle Synopsis
- * In inertially confined fusion, ignition allows the fusion process to spread into surrounding fuel, potentially leading to higher energy output.
- * Recent experiments at the National Ignition Facility achieved capsule gains of 5.8 and approached ignition, even though "scientific breakeven" has not yet been fully realized.