Publications by authors named "P J Bousquet"
Record breaking atmospheric methane growth rates were observed in 2020 and 2021 (15.2±0.5 and 17.
View Article and Find Full Text PDFObjectives: To propose a new flap design that utilize a minimally invasive approach to move implants. We also propose a 3D method to track changes in implant position without the need for CBCT.
Materials And Methods: Implants were inserted in two mongrel dogs then a minimally invasive tunnel like flap was made.
Improving the diffraction quality of heat-shock protein 47 crystals.
Acta Crystallogr F Struct Biol Commun
November 2024
Heat-shock protein 47 (HSP47) is a potential target for inhibitors that ameliorate fibrosis by reducing collagen assembly. In an effort to develop a structure-based drug-design system, it was not possible to replicate a previous literature result (PDB entry 4au4) for apo dog HSP47; instead, crystal forms were obtained in which pairs of dog HSP47 molecules interacted through a noncleavable C-terminal His-tag to build up tetramers, all of which had multiple molecules of HSP47 in the asymmetric unit and none of which diffracted as well as the literature precedent. To overcome these difficulties, a two-pronged approach was followed: (i) the His-tag was moved from the C-terminus to the N-terminus and was made cleavable, and (ii) Adnectin (derived from the tenth domain of human fibronectin type III) crystallization chaperones were developed.
View Article and Find Full Text PDFArticle Synopsis
- A study examined the cancer risk in people with multiple sclerosis (PwMS) compared to a matched sample from the general French population over a 10-year period, using national health data.
- Among the 140,649 PwMS, the incidence of cancer was found to be slightly higher (799 per 100,000 person-years) than that of the matched controls (736 per 100,000 person-years), indicating a small overall increased risk for PwMS.
- The risk for different cancer types varied, with higher risks for bladder, brain, and cervical cancers, while prostate, breast, and colorectal cancers showed a lower risk in PwMS.
Background: The impact of antibiotics (ATBs) on the risk of colorectal cancer (CRC) recurrence after curative resection remains unknown.
Methods: Using the French nation-wide database of cancer patients, all newly diagnosed non-metastatic CRC patients resected between 01/2012 and 12/2014 were included. The perioperative ATB intake (from 6 months before surgery until 1 year after) was classified according to the class, the period of use (pre- vs post-resection), the disease stage (localized and locally advanced), and the primary tumor location (colon and rectum/junction).