Prospective multicenter evaluation of the morphometric D-score for prediction of the outcome of endometrial hyperplasias.

Prospective multicenter evaluation of the WHO classification and the morphometric D-score to predict endometrial hyperplasia cancer progression. In 132 endometrial hyperplasias WHO classification was performed by two experienced gynecologic pathologists. The D-score was assessed blindly by technicians in a routine diagnostic setting.

Ki-67 immunoquantitation in cervical intraepithelial neoplasia (CIN): a sensitive marker for grading.

The aim of this study was to assess the value of Ki-67 immunoquantitation with a computerized image analysis system for grading support in cervical intraepithelial neoplasia (CIN). Sixty-five 'blind' consensus biopsies (23 CIN 1, 22 CIN 2, and 20 CIN 3) were used as a learning set. Measurements were done in the carefully selected most severely dysplastic part of the epithelium of each CIN case.

[Therapeutic procedure and long-term results in tibial pilon fracture in relation to primary soft tissue damage].

Between 1980 and 1990, 81 fractures of the pilon tibial of type B or C in the AO classification, presenting in 78 patients, were treated operatively in the Department of Traumatology and Emergency Surgery of the University Hospitals of Leuven. One-fourth of the fractures were open, 36 had second- or third-degree soft tissue damage according to the Tscherne classification system. The relationship between the fracture type and soft tissue damage was significant: the more severe the soft tissue damage, the more complex the fracture type.

Surgical management of pelvic ring disruptions. Indications, techniques and functional results.

In a period of 30 months, we treated 44 pelvic ring fractures by early operative stabilization. The ratio of associated musculoskeletal and intrapelvic lesions was very high, with a mean ISS of 36.2.

Single-dose prophylaxis in hysterectomies. An interim analysis.

The efficacy of single-dose prophylaxis with intravenous cefuroxime 1,500 mg plus 500 mg metronidazole in vaginal or abdominal hysterectomies was investigated in a randomized, double-blind, placebo-controlled study, involving 396 evaluable patients. A significant reduction of the number in urinary tract infections was observed in the groups undergoing abdominal hysterectomy or vaginal hysterectomy with vaginal repair. The incidence of wound infections and the duration of hospitalization were significantly reduced in patients undergoing vaginal hysterectomy with or without vaginal repair.