Hyperkeratosis lenticularis perstans (Flegel).

2 patients with typical clinical and histological pictures of hyperkeratosis lenticularis perstans were described. Both patients showed abnormalities of the mucosal surface. The ultrastructural findings, both in the cutaneous and in the mucosal lesions, provide strong evidence that the mucosal abnormalities are a real component of hyperkeratosis lenticularis perstans.

Dithiocarbamate therapy for nickel dermatitis.

Increased internal exposure to nickel can cause an exacerbation of nickel contact dermatitis. Nickel ions are chelated by diethyldithiocarbamate (DDC) and thereby inactivated. An oral dose of about 1 g DDC/day was given to a patient.

Factors influencing nickel dermatitis. I.

The nickel concentrations in urine and blood plasma of a very hypersensitive female patient have been followed during two periods of 34 and 42 days each. A limited degree of correlation was found between the course of the nickel concentration in plasma, the nickel concentration in urine and the clinical activity of the dermatitis. Evidently other factors also influence the activity of the dermatitis; among these menstruation and stress might be expected to play a role.

Nickel content of plasma, urine and hair in contact dermatitis.

The nickle (Ni) concentrations of blood plasma, urine and scalp hair do not differ between hypersensitive and non-hypersensitive subjects. Those who are occupationally exposed have about ten times the control content of nickel in the plasma, urine and hair, whether hypersensitive or not. During vacations the Ni contents of their plasmas and urines decrease sharply.