Publications by authors named "P J Blind"
Article Synopsis
- The study aimed to examine how total REBOA (tREBOA) affects cerebral blood flow and intracranial pressure (ICP) in pigs during controlled hemorrhagic shock and subsequent resuscitation.
- Researchers used 22 anesthetized pigs, splitting them into two groups: one with elevated ICP (EICPG) and one with normal ICP (NICPG), and monitored their vital parameters before and after inducing shock.
- Results showed that tREBOA effectively restored cerebral perfusion in both groups, even with periods of impaired autoregulation, confirming its potential as a lifesaving intervention during critical resuscitation scenarios.
Aims: The activity of the sympathetic nervous system (SNS) is crucial at an early stage in the development of an inflammatory reaction. A study of metabolic events globally and locally in the early phase of acute pancreatitis (AP), implying hampered SNS activity, is lacking. We hypothesized that thoracic epidural anaesthesia (TEA) modulates the inflammatory response and alleviates the severity of AP in pigs.
View Article and Find Full Text PDFBackground: Ischemic injury of an organ causes metabolic change from aerobic to anaerobic metabolism. It has been shown in experimental studies on the heart and liver that such conversion may be detected by conventional microdialysis probes placed intra-parenchymatously, as well as on organ surfaces, by assaying lactate, pyruvate, glucose, and glycerol in dialysate. We developed a microdialysis probe (S-μD) intended for use solely on organ surfaces.
View Article and Find Full Text PDFBackground: To investigate whether surface microdialysis (μD) sampling in probes covered by a plastic film, as compared to noncovered and to intraparenchymatous probes, would increase the technique's sensitivity for pathophysiologic events occurring in a liver ischemia-reperfusion model. Placement of μD probes in the parenchyma of an organ, as is conventionally done, may cause adverse effects, e.g.
View Article and Find Full Text PDFBackground/aims: Fast-track programs involving multi-modal measures to enhance recovery after surgery, reduce morbidity and decrease hospital length of stay (LOS) are used for different major surgical procedures. For liver resections, factors influencing LOS within a fast-track program have been studied only to a limited extent, which was the aim of the present study.
Methodology: The present study comprises the first 64 patients included in a fast-track program for liver resections introduced in March 2012.