Domain architecture of the MabR (), a member of the PucR transcription factor family.

MabR (), a PucR-type transcription factor, plays a crucial role in regulating mycolic acid biosynthesis in . To understand its regulatory mechanisms, we determined the crystal structures of its N-terminal and C-terminal domains. The N-terminal domain adopts a globin-like fold, while the C-terminal domain comprises an α/β GGDEF domain and an all-α effector domain with a helix-turn-helix DNA-binding motif.

Detection of florfenicol resistance in opportunistic spp. infections in rural Thailand.

Florfenicol (Ff) is an antimicrobial agent belonging to the class amphenicol used for the treatment of bacterial infections in livestock, poultry, and aquaculture (animal farming). It inhibits protein synthesis. Ff is an analog of chloramphenicol, an amphenicol compound on the WHO essential medicine list that is used for the treatment of human infections.

Extended blood stage sensitivity profiles of to doxycycline and tafenoquine, as a model for .

Testing antimicrobial sensitivity is limited to schizont maturation assays, which preclude determining the IC50s of delayed action antimalarials such as doxycycline. Using as a model for , we determined the physiologically significant delayed death effect induced by doxycycline [IC, 1,401 ± 607 nM]. As expected, IC to chloroquine (20.

Differential mucosal tropism and dissemination of classical and hypervirulent infection.

(Kp) infection is an important healthcare concern. The ST258 classical (c)Kp strain is dominant in hospital-acquired infections in North America and Europe, while ST23 hypervirulent (hv)Kp prevails in community-acquired infections in Asia. This study aimed to develop symptomatic mucosal infection models in mice that mirror natural infections in humans to gain a deeper understanding of Kp mucosal pathogenesis.