Publications by authors named "P J Barthel"
In contemporary healthcare, effective risk stratification in the general population is vital amidst rising chronic disease rates and an ageing demographic. Deceleration Capacity of the heart rate (DC), derived from 24-hour Holter electrocardiograms, holds promise in risk stratification for cardiac patients. However, the potential of short-term electrocardiograms of five minutes duration for population screening has not been fully explored.
View Article and Find Full Text PDFGenetic alterations in the ERCC4 gene typically cause Xeroderma pigmentosum and other nucleotide excision repair disorders. Neurologic symptoms are present in some of these patients. In rare cases, ERCC4-mutations can manifest with prominent neurologic symptoms.
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- This study looks at how well doctors can predict sudden cardiac death after someone has a heart attack using a measurement called left ventricular ejection fraction (LVEF).
- They combined information from over 140,000 heart attack patients to see if LVEF alone is good enough for deciding who should get a heart device called a defibrillator.
- The results showed that LVEF didn't do a great job at predicting sudden cardiac death, which means doctors need better ways to tell who is at risk.
Article Synopsis
- Heart failure with preserved ejection fraction (HFpEF) involves dysfunctional heart muscle cells and is associated with stiffening of the protein titin, affecting muscle performance and leading to exercise intolerance.
- This study investigated how titin and related proteins are altered in limb and diaphragm skeletal muscle in a rat model of HFpEF, discovering that titin hyperphosphorylation in limb muscles contributes to muscle stiffness and reduced force capabilities.
- High-intensity interval training (HIIT) was found to reverse this hyperphosphorylation in the limb muscles, while the diaphragm showed no such changes, indicating different responses in skeletal muscle types and further linking titin stiffening to exercise intolerance in HFpEF.
Background: Clinical studies demonstrated beneficial effects of sodium-glucose-transporter 2 inhibitors on the risk of cardiovascular death in patients with heart failure with preserved ejection fraction (HFpEF). However, underlying processes for cardioprotection remain unclear. The present study focused on the impact of empagliflozin (Empa) on myocardial function in a rat model with established HFpEF and analyzed underlying molecular mechanisms.
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