Publications by authors named "P J Barta"
Infectious diseases, including bacterial, fungal, and viral, have once again gained urgency in the drug development pipeline after the recent COVID-19 pandemic. Tuberculosis (TB) is an old infectious disease for which eradication has not yet been successful. Novel agents are required to have potential activity against both drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis (Mtb), the causative agent of TB.
View Article and Find Full Text PDFIntroduction: The Swedish Sleep Apnea Registry (SESAR) collects clinical data from individual obstructive sleep apnea (OSA) patients since 2010. SESAR has recently been integrated with additional national healthcare data. The current analysis presents the SESAR structure and representative clinical data of a national sleep apnea cohort.
View Article and Find Full Text PDFA new series of potential flutamide-like antiandrogens has been designed and synthesized to treat prostate cancer. This new series results from our research, which has been aimed at discovering new compounds that can be used for androgen deprivation treatment. The antiandrogens were designed and synthesized by varying the acyl part, linker, and substitution of the benzene ring in the 4-nitro-3-trifluoromethylanilide scaffold of non-steroidal androgens.
View Article and Find Full Text PDFArticle Synopsis
- The study looked at how a protein called megalin affects the way certain radioactive peptides are taken into kidney cells, which can be harmful.
- Researchers created a special type of kidney cell (called LRP2 knockout) using a gene-editing tool called CRISPR to see how the peptides behave without megalin.
- They found that these modified cells took in the radioactive peptides less than the normal cells, helping them understand the role of megalin in this process better.
Monozygotic Twins with Legg-Calvé-Perthes Disease and with Non-Identical Lumbosacral Malformation: a Case Report and Literature Review.
Acta Chir Orthop Traumatol Cech
October 2023
Article Synopsis
- The authors discuss two monozygotic male twins diagnosed with right-sided Legg-Calvé-Perthes disease (LCPD) who exhibit different formations of their lumbosacral junction.
- While both twins were treated for LCPD during childhood, Twin A has a fusion of the L5 transverse process with the sacral ala, whereas Twin B has complete sacralization of the fifth lumbar vertebra.
- Despite this morphological difference, the twins' treatment outcomes align with larger studies, indicating that the age of LCPD onset is crucial for prognosis.