Publications by authors named "P J Babin"
The main objective of the ZebraCool programme was to create a positive attitude and curiosity towards science by bringing experimental activities within schools using an introductory cognitive and sensory approach. This innovative programme was offered at all levels of primary and secondary education including vocational high schools. Thematic workshops can be carried out on various themes such as comparative anatomy and embryology, molecular biology and evolution, or toxicology and endocrine disruptors.
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- In Europe, rodent studies are the main method used to assess neurotoxicity, but they are expensive and raise ethical concerns, leading many to seek alternatives.
- There is a growing public demand for safer chemicals, as many on the market haven't been thoroughly tested for neurotoxic effects, prompting research into New Approach Methods (NAMs) to replace animal testing.
- The European Partnership for the Assessment of Risks from Chemicals (PARC) is working on NAMs to evaluate neurotoxicity, aiming to create faster and cheaper testing methods that can help regulatory agencies and industries improve safety assessments.
The prevalence of metabolic diseases, such as obesity, diabetes, metabolic syndrome and chronic liver diseases among others, has been rising for several years. Epidemiology and mechanistic (in vivo, in vitro and in silico) toxicology have recently provided compelling evidence implicating the chemical environment in the pathogenesis of these diseases. In this review, we will describe the biological processes that contribute to the development of metabolic diseases targeted by metabolic disruptors, and will propose an integrated pathophysiological vision of their effects on several organs.
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