Publications by authors named "P J Ashonibare"
Testicular torsion is a urological emergency that involves the twisting of the spermatic cord along its course. Compelling pieces of evidence have implicated oxidative stress-sensitive signaling in pathogenesis of testicular I/R injury. Although, surgical detorsion is the mainstay management; blockade of the pathways involved in the pathogenesis may improve the surgical outcome.
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- The gut microbiota significantly impacts physiological processes, especially in reproduction, with emerging evidence of a gut microbiota-gonadal interaction.
- This study reviews how gut microbiota influences reproductive functions by affecting hormone levels, insulin sensitivity, and immune responses.
- While animal studies show promise regarding this gut-gonadal connection, more human research is needed to validate these findings and understand their implications.
Sodium acetate abates lead-induced sexual dysfunction by upregulating testosterone-dependent eNOS/NO/cGMP signaling and activating Nrf2/HO-1 in male Wistar rat.
Naunyn Schmiedebergs Arch Pharmacol
February 2024
Oxidative stress has been linked with lead toxicity, including lead-induced sexual dysfunction. On the contrary, sodium acetate has been proven to exert antioxidant activity. However, the effect of sodium acetate on lead-induced sexual dysfunction has not been fully explored.
View Article and Find Full Text PDFAim: This study evaluated the effect of lead, with or without zinc co-administration, on steroidogenic and xanthine oxidase (XO)/uric acid (UA)/caspase 3-mediated apoptotic signaling in the testis.
Materials And Methods: Forty male Wistar rats were divided into four groups at random; vehicle-treated control, zinc-treated, lead-treated, and lead + zinc-treated groups.
Results: Lead exposure significantly lowered overall weight gain, testicular, epididymal, seminal vesicle, and prostate weights.
Zinc improves sexual performance and erectile function by preventing penile oxidative injury and upregulating circulating testosterone in lead-exposed rats.
Redox Rep
December 2023
Aim: The present study evaluated the effect of lead exposure with and without zinc therapy on male sexual and erectile function.
Methods: Twenty male Wistar rats were randomly assigned into four groups; the control, zinc-treated, lead-exposed, lead + zinc-treated groups. Administrations were per os daily for 28 days.