Publications by authors named "P J A Hutchinson"
Background: The oxygen reactivity index (ORx) reflects the correlation between focal brain tissue oxygen (pbtO) and the cerebral perfusion pressure (CPP). Previous, small cohort studies were conflicting on whether ORx conveys cerebral autoregulatory information and if it is related to outcome in traumatic brain injury (TBI). Thus, we aimed to investigate these issues in a larger TBI cohort.
View Article and Find Full Text PDFBackground: Entropy quantifies the level of disorder within a system. Low entropy reflects increased rigidity of homeostatic feedback systems possibly reflecting failure of protective physiological mechanisms like cerebral autoregulation. In traumatic brain injury (TBI), low entropy of heart rate and intracranial pressure (ICP) predict unfavorable outcome.
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- * A secondary analysis found that patients in the CPPopt-targeted group had better autoregulation, indicated by a significantly lower median ΔPRx during preserved autoregulation periods compared to the control group.
- * The study concludes that while there was no noticeable difference in overall PRx averages, targeting CPPopt appears to enhance cerebrovascular reactivity in TBI patients.