Methotrexate in the treatment of mycosis fungoides - a multicenter observational study in 79 patients.

Objective: The first report concerning methotrexate (MTX) in the treatment of Mycosis fungoides (MF) was published in 1964 by Wright. The mechanism of MTX action in the treatment of primary cutaneous T-cell lymphoma (CTCL) has been not explained in detail yet (the anti-inflammatory, immunomodulating, immunosuppressive, and cytostatic actions have been under discussion).

Patients And Methods: This is a retrospective analysis of 79 MF patients in 4 dermatology clinical centers in Poland.