Publications by authors named "P Iorio"
Article Synopsis
- Paranasal sinuses can help identify individuals by comparing post-mortem CT (PMCT) scans with ante-mortem CT (AMCT) scans, but security issues arise when sharing raw AMCT images for suspected identities.
- The study aimed to create an identification score, called IDScore, by analyzing CT slices from two successive AMCTs and assessing their similarities among radiologists.
- The validated IDScore method achieved perfect identification rates (100% sensitivity and specificity) without needing to access full AMCT images, addressing ethical concerns during identity verification.
Article Synopsis
- Glioblastoma multiforme (GBM) releases extracellular vesicles (EVs) that can transfer aggressive traits to other cells, making the study of these vesicles crucial for understanding tumor behavior.
- * EV proteins are being investigated to find new biomarkers and targets for treatment, with proteomic studies primarily using "bottom-up" mass spectrometry on EVs from GBM cells and patient fluids.
- * Despite identifying many dysregulated proteins, clinical translation is challenging due to inconsistent EV isolation methods and proteome analysis, highlighting the need for standardized techniques and exploring protein mutations to improve GBM therapies.*
Article Synopsis
- The study examines how affective temperaments influence the risk of developing seasonal affective disorder (SAD) among young adults without prior clinical diagnoses.
- Participants included 846 university students who completed questionnaires to evaluate their seasonal mood issues and temperament types.
- Results showed that individuals with cyclothymic and anxious temperaments are more vulnerable to SAD, while those with hyperthymic temperament are less affected, suggesting that understanding these temperaments can improve assessment and predictions for SAD.
Neurodegenerative diseases and brain tumours represent important health challenges due to their severe nature and debilitating consequences that require substantial medical care. Interestingly, these conditions share common physiological characteristics, namely increased glutamate, and adenosine transmission, which are often associated with cellular dysregulation and damage. Guanosine, an endogenous nucleoside, is safe and exerts neuroprotective effects in preclinical models of excitotoxicity, along with cytotoxic effects on tumour cells.
View Article and Find Full Text PDFExtracellular vesicles (EVs) are secreted from many tumors, including glioblastoma multiforme (GBM), the most common and lethal brain tumor in adults, which shows high resistance to current therapies and poor patient prognosis. Given the high relevance of the information provided by cancer cell secretome, we performed a proteomic analysis of microvesicles (MVs) and exosomes (EXOs) released from GBM-derived stem cells (GSCs). The latter, obtained from the brain of GBM patients, expressed P2X7 receptors (P2X7Rs), which positively correlate with GBM growth and invasiveness.
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