Publications by authors named "P Im"
Excessive reactive oxygen species (ROS) generated by ultraviolet (UV) irradiation significantly contribute to photoaging by increasing the level of matrix metalloproteinases (MMPs), accelerating collagen degradation. Commercial dermal fillers offer temporary wrinkle reduction via volume enhancement. In this study, we propose tilapia-derived collagen hydrogels embedded with ceria nanoparticles (Ce@Col gels) as long-lasting dermal fillers for UVB-induced photoaging.
View Article and Find Full Text PDFThe development of highly effective hemostatic materials with high biocompatibility and outstanding performance is vital to the field of biomaterials. In this study, we develop a hemostatic fiber material that exhibits high biocompatibility and excellent performance. By incorporating polydopamine (PDA) into the alkaline treatment of silk fibroin (SF), we achieve PDA-coated SF fibers with lengths that can be controlled by the alkaline concentration.
View Article and Find Full Text PDFTilapia-Derived Granular Hydrogel as a 3D Scaffold Promoting Rapid Wound Healing.
Biomacromolecules
February 2024
The skin, a crucial organ that protects the body, is vulnerable to external damage. Traditional tissue regeneration methods, including bulk hydrogels, aim to facilitate wound healing by interacting with host cells and providing a conducive environment. However, the nanoscale porosity of conventional hydrogels limits cell penetration and tissue regeneration.
View Article and Find Full Text PDFArticle Synopsis
- Alcohol-related liver disease (ARLD) is a significant public health issue, and identifying high-risk individuals can enhance public health strategies.
- In a study of 312,599 active drinkers from the UK Biobank, both binge drinking and genetic predisposition (measured using a polygenic risk score, PRS) were found to significantly increase the risk of alcohol-related cirrhosis (ARC).
- Diabetes also raised ARC risk across all drinking patterns and genetic categories, highlighting a complex interplay between drinking behavior, genetics, and diabetes that offers potential for targeted interventions in high-risk individuals.
Background: Genetic variants that affect alcohol use in East Asian populations could help assess the causal effects of alcohol consumption on cause-specific mortality. We aimed to investigate the associations between alcohol intake and cause-specific mortality using conventional and genetic epidemiological methods among more than 512 000 adults in China.
Methods: The prospective China Kadoorie Biobank cohort study enrolled 512 724 adults (210 205 men and 302 519 women) aged 30-79 years, during 2004-08.