Serum ganglioside patterns in multiple sclerosis.

The relative distribution of gangliosides was determined in the serum of 37 patients with multiple sclerosis (MS) and of 30 healthy subjects. There was a significant increase of GM1 and GD1a, and a decrease of GM3 proportion in the serum of relapsing-remitting MS patients (RRMS) during their first MS attack. The RRMS patients in relapse with a long duration of the disease had a significant decrease of GM1 and an increase of GD1a portion in the serum.

[Cholesterol ester-composition of the adrenal glands of rats in various fat-rich diet regimes].

Cells of adrenal cortex (AC) contain in about 80-90% cholesterol esters (CE), related to total cholesterol. It is assumed, that dietary fats can influence the composition of CE and hydrolytic activity of AC, leading to disorders in steroid biosynthesis. Results are presented about fatty acid composition of CE of AC from rats, fed with a fat rich diet containing different dietary fats.

The experimental obesity by high-fat feeding--a model for evaluation of the biological value of fats.

The experimental obesity by high-fat feeding of rats, introduced after weaning, was found to be a suitable model for evaluation of the biological value of nutritional fats with different fatty acid composition: butter (group B), lard (L), partially hydrogenated oil (H), lard + sunflower oil 2:1 (LS). The differences in the fatty acid composition of these regimens affect: the efficiency in creating the model of obesity; the hormonal pattern of blood plasma; some metabolic pathways in liver and adipose tissue (especially in group H); the fatty acid composition of some structural, reserve and transport lipids; some biological tests indicative of membrane's phospholipid and fatty acid composition, i.e.