Towards the Application of a Label-Free Approach for Anti-CD47/PD-L1 Bispecific Antibody Discovery.

The engineering of bispecific antibodies that exhibit optimal affinity and functional activity presents a significant scientific challenge. To tackle this, investigators employ an assortment of protein assay techniques, such as label-free interaction methodologies, which offer rapidity and convenience for the evaluation of extensive sample sets. These assays yield intricate data pertaining to the affinity towards target antigens and Fc-receptors, instrumental in predicting cellular test outcomes.

Targeted depletion of TRBV9 T cells as immunotherapy in a patient with ankylosing spondylitis.

Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy grail of autoimmune therapy, but disease-associated T cell receptors (TCRs) and cognate antigenic epitopes remained elusive. A TRBV9-containing CD8 TCR motif was recently associated with the pathogenesis of ankylosing spondylitis, psoriatic arthritis and acute anterior uveitis, and cognate HLA-B*27-presented epitopes were identified.

[Clinico-morphological comparisons in patients with toxic goiter].

The article presents a comparison and analysis of clinical and morphological data obtained in surgical treatment of 743 thyrotoxicosis patients operated in clinical bases of the Saint Petersburg Center of surgery of organs of the endocrine system at the period from 2005 through 2010. Causes of disagreement of the clinical diagnosis and morphological conclusion in patients with different diseases of the thyroid gland resulting in thyrotoxicosis are considered. Great clinical material (743 observations) was used by the authors to demonstrate the diagnostic value of special methods of investigation of the thyroid gland in patients with the toxic goiter.