Publications by authors named "P I Sciancalepore"
Article Synopsis
- Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) is a rare autoimmune disorder linked to antiphospholipid syndrome, which causes severe bleeding due to low prothrombin levels, as illustrated by a case study of a 34-year-old woman with heavy menstrual bleeding and related complications.
- The patient underwent extensive testing, revealing deficiencies in factors II and IX, leading to the initiation of immunosuppressive treatment with Rituximab and hormonal therapy with desogestrel to manage antibody levels and reduce bleeding.
- After one year of treatment, the patient achieved complete remission, with restored levels of prothrombin and factor IX while showing reduced antibody
Association of human leucocyte antigen loci with vaccine-induced immune thrombotic thrombocytopenia: Potential role of the interaction between platelet factor 4-derived peptides and MHC-II.
Br J Haematol
January 2025
No risk factors have been identified for vaccine-induced immune thrombotic thrombocytopenia (VITT) so far. The aim of this study was to identify human leucocyte antigen (HLA) alleles potentially associated with VITT susceptibility. Specific HLA class II alleles were detected with significantly higher frequency in VITT patients compared with Italian controls: DPB1*17:01, DQA1*05:01, and DRB1*11:04.
View Article and Find Full Text PDFAs a consequence of the outbreak of SARS-CoV-2, the clinical practice of otolaryngologists underwent profound transformations. Non-aerosol-generating procedures have been researched and implemented. Transcutaneous laryngeal ultrasonography (TLUSG) provides a rapid and noninvasive method to assess laryngeal function and can support the management of laryngeal disorders.
View Article and Find Full Text PDFThe aim of our study was to assess whether a polymer-based e-nose can distinguish head and neck cancer subjects from healthy controls, as well as from patients with allergic rhinitis. A total number of 45 subjects participated in this study. The first group was composed of 15 patients with histology confirmed diagnosis of head and neck cancer.
View Article and Find Full Text PDFUnlabelled: During the Coronavirus Disease 2019 (COVID-19) pandemic, otolaryngology has been shown to be a high-risk specialty due to the exposure to aerosol-generating physical examinations, procedures and surgical interventions on the head and neck area, both in adult and paediatric patients. This has prompted the issue of updating the guidelines by International Health Authorities in the Ear Nose and Throat (ENT) field and, at the same time, has stimulated engineers and healthcare professionals to develop new devices and technologies with the aim of reducing the risk of contamination for physicians, nurses and patients.
Methods: A review of the literature published on PubMed, Ovid/Medline and Scopus databases was performed from January 01, 2020 to December 31, 2021.