Publications by authors named "P I Pressman"
Introduction: Psychotropic medication (PM) use in behavioral-variant frontotemporal dementia (bvFTD) is higher than in other dementias. However, no information exists on whether PM use differs between sporadic and genetic bvFTD.
Methods: We analyzed data from sporadic and genetic bvFTD participants with PM prescriptions in the Advancing Research and Treatment in Frontotemporal Lobar Degeneration/Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects study.
The present paper provides the first documentation and assessment of the capacity of chlorogenic acid to induce hormetic dose-response relationships. The findings suggest that chlorogenic acid may induce anabolic (i.e.
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- A diagnosis of behavioral variant frontotemporal dementia (bvFTD) often depends on reports from informants about noticeable behavioral changes in patients.
- The term "bvFTD-by-proxy" refers to cases where changes are reported only by informants, which can lead to questions about the reliability of their observations.
- Three case studies illustrated that symptoms resembling bvFTD were reported by spouses, but medical tests showed only mild issues, highlighting the risks of inaccurate informant reports and the need for careful, coordinated care to protect patient autonomy.
Rosmarinic acid is a polyphenol found in numerous fruits and vegetables, consumed in supplement form, and tested in numerous clinical trials for therapeutic applications due to its putative chemopreventive properties. Rosmarinic acid has been extensively studied at the cellular, whole animal, and molecular mechanism levels, presenting a complex array of multi-system biological effects. Rosmarinic acid-induced hormetic dose responses are widespread, occurring in numerous biological models and cell types for a broad range of endpoints.
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- Caffeic acid, a phenolic compound found in coffee and various fruits and vegetables, is recognized for its antioxidant benefits and is commonly used as a dietary supplement in multiple forms.
- The review paper discusses how caffeic acid displays hormetic effects, which means it can stimulate or inhibit biological responses depending on the concentration used, impacting processes related to aging.
- The authors analyze existing biomedical literature on caffeic acid's hormetic responses, discuss their potential implications for health, and suggest areas for future research.