Publications by authors named "P I Parker"
Introduction: Clinicians are the conduits of high-quality care delivery. Clinicians have driven advancements in pharmacotherapeutics, devices, and related interventions and improved morbidity and mortality in patients with congestive heart failure over the past decade. Yet, the management of congestive heart failure has become extraordinarily complex and has fueled recommendations from the American Heart Association and the American College of Cardiology to optimize the composition of the care team to reduce the health, economic, and the health system burden of high lengths of stay and hospital charges.
View Article and Find Full Text PDFThe mutually antagonistic relationship of atypical protein kinase C (aPKC) and partitioning-defective protein 6 (Par6) with the substrate lethal (2) giant larvae (Lgl) is essential for regulating polarity across many cell types. Although aPKC-Par6 phosphorylates Lgl at three serine sites to exclude it from the apical domain, aPKC-Par6 and Lgl paradoxically form a stable kinase-substrate complex, with conflicting roles proposed for Par6. We report the structure of human aPKCι-Par6α bound to full-length Llgl1, captured through an aPKCι docking site and a Par6 contact.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how reallocating time among physical activity, sedentary behavior, and sleep affects obesity indicators like BMI and waist circumference across various age groups.
- Researchers analyzed data from 9,818 participants using isotemporal substitution models to understand the implications of these behavior changes.
- Results indicated that even small shifts of 10-30 minutes can significantly impact obesity, with reallocating moderate-to-vigorous physical activity (MVPA) to lighter activities or sedentary behavior having particularly detrimental effects.
Background: Clinical genetic evaluation of dilated cardiomyopathy (DCM) is implemented variably or not at all. Identifying needs and barriers to genetic evaluations will enable strategies to enhance precision medicine care.
Methods: An online survey was conducted in June 2024 among cardiologist investigators of the DCM Consortium from US advanced heart failure/transplant (HF/TX) programs to collect demographics, training, program characteristics, genetic evaluation practices for DCM, and implementation needs.
"Increasing body mass index is associated with intensive care unit admission and severe maternal morbidity".
J Matern Fetal Neonatal Med
December 2025
Objective: This study aimed to assess the relationship between increased body mass index (BMI) with severe maternal morbidity (SMM).
Study Design: We obtained data for a retrospective cohort of singleton live births using an electronic birth certificate database from 2010 to 2022 in Central New York. Institutional review board exemption was obtained.