[Efficiency of emoxipine in treatment of multiple organ failure in newborns].

Prospective, placebo-controlled, simple "blind" randomized study of the effect of emoxipine (2-ethyl-6-methyl-3-oxypyridine hydrochloride) on the dynamics of central hemodynamics, content of lipid peroxidation products in tracheo-bronchial lavage, and severity of clinical sickness was performed in newborn children with multiple organ failures (MOF). The obtained results showed that a 10-day course of the intravenous administration of emoxipine in a single dose of 10 mg/kg improved the systolic function of myocardium of left ventricle, limited lipid peroxidation in broncho-pulmonary system, and increased oxygen delivery to tissues. These effects of emoxipine were accompanied by a clinically significant improvement of neurological status, reduction of the need for artificial ventilation of lungs, and decrease of mortality in newborns with MOF diagnosis.

[Immunoenzyme analysis and polymerase chain reaction in the diagnosis of an intrauterine infection in newborn infants with cerebral lesions].

The comparative evaluation of the diagnostic value of the polymerase chain reaction (PCR) and the enzyme immunoassay (EIA) in the detection of intrauterine infection (IUI) in 48 newborn infants with cerebral lesions was made. Tests for the presence of the infective agents of IUI, most frequently occurring in the region (Cytomegalovirus, Herpes simplex virus, Chlamydia trachomatis), were carried out. The levels of serum IgA, IgG and IgM were evaluated in the course of the primary screening of IUI.