Publications by authors named "P I Borel"
Background: Adipose tissue vitamin A (VA), that is, mainly retinol (RET) and its esters, comes from preformed VA and proVA carotenoids present in our food. Adipose tissue VA acts as hormonal cue maintaining essential aspects of adipocyte biology, which includes fat mobilization and catabolism, energy balance, and glucose homeostasis, and it is thus of particular interest to study its determinants, including genetic ones.
Objectives: This study aimed to identify genetic variations associated with adipose tissue VA concentration.
Characterization of the interindividual variability of lutein and zeaxanthin concentrations in the adipose tissue of healthy male adults and identification of combinations of genetic variants associated with it.
Food Funct
September 2024
Lutein (L) and zeaxanthin (Z) are involved in visual function and could prevent age-related macular degeneration and chronic diseases and improve cognitive performances. Adipose tissue is the main storage site for these xanthophylls (Xanth). The factors affecting their concentrations in this tissue remain poorly understood but in animal models, genetic variations in apolipoprotein E and β-carotene oxygenase 2 have been associated with adipose tissue L concentration.
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- * Researchers analyzed α-TOC concentrations in fasting plasma and adipose tissue from 42 healthy male participants, finding significant variability in adipose tissue α-TOC levels but no correlation with fasting plasma levels.
- * A model using 10 specific genetic variations (SNPs) explains 60% of the differences in adipose tissue α-TOC concentration, suggesting that genetics play a role in how the body stores and processes this vitamin. *
Article Synopsis
- Several studies suggest that lycopene and tomato products may enhance metabolic health, particularly in environments that promote obesity.
- The research involved 80 male mice fed different diets supplemented with tomato powders from various genotypes, exploring their effects on obesity-related health issues.
- Results showed that certain tomato genotypes improved fasting blood sugar and reduced liver fat, with one genotype (IL6-2) notably decreasing body weight and improving glucose levels, while irrigation levels had little effect on these health benefits.
Article Synopsis
- - Drought significantly impacts horticulture, particularly fruit quality and nutritional value, which has been less studied despite its importance.
- - In a study analyzing six tomato genotypes and one goji cultivar under deficit irrigation (DI), it was found that DI increased certain health-related compounds, like phenolics and sugars, while negatively affecting ascorbic acid and decreasing total carotenoids in tomatoes.
- - The study revealed that while DI concentrated some nutrients in the fruits, it did not always enhance their bioaccessibility, meaning that higher concentrations of metabolites did not guarantee better absorption in the body, varying by plant species and genotype.