Publications by authors named "P Huebener"
Background: High-mobility group box protein 1 [HMGB1] is a ubiquitous nucleoprotein with immune-regulatory properties following cellular secretion or release in sterile and in infectious inflammation. Stool and serum HMGB1 levels correlate with colitis severity and colorectal cancer [CRC] progression, yet recent reports indicate that HMGB1 mainly operates as an intracellular determinant of enterocyte fate during colitis, and investigations into the roles of HMGB1 in CRC are lacking.
Methods: Using mice with conditional HMGB1-knockout in enterocytes [Hmgb1ΔIEC] and myeloid cells [Hmgb1ΔLysM], respectively, we explored functions of HMGB1 in pathogenetically diverse contexts of colitis and colitis-associated CRC.
Article Synopsis
- Periodontitis is commonly diagnosed in patients with ascitic decompensated liver cirrhosis, found in 82% of the study group compared to 59% in a control group, suggesting a strong correlation between the two conditions.
- The study utilized PCR testing on gingival samples, ascites, and stool but found no evidence of specific periodontitis pathogens in ascites, although some were present in stools and gums.
- Patients with periodontitis showed a significantly higher survival rate and transplant-free survival compared to those without, indicating a potential protective effect of periodontitis in this cohort.
Background & Aims: Acute pancreatitis (AP) is a frequent indication for hospitalization and may present with varying degrees of severity. AP often coincides with hepatic disease, yet the impact of liver cirrhosis (LC) on the course of AP is uncertain, and early identification of patients at risk for complications remains challenging. We aimed to assess the impact of LC on the development of pancreatic and extra-pancreatic complications of AP, and to identify predictors of adverse outcomes in cirrhotic patients.
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- Fibrosis is responsible for about 45% of deaths in western countries and significantly affects outcomes in chronic liver disease, but effective treatments are lacking.
- Researchers explored the role of damage-associated molecular patterns (DAMPs) and identified the purinergic receptor P2Y14 as a key receptor in liver fibrosis, particularly in hepatic stellate cells (HSCs).
- The study showed that ligands for P2Y14 are released during cell death and activate fibrogenic processes, indicating this receptor could be a potential target for antifibrotic therapies in liver injury.