Association of endothelial protein C receptor haplotypes, factor V Leiden and recurrent first trimester pregnancy loss.

Objectives: We evaluated whether the endothelial protein C receptor (EPCR) haplotypes A1 and A3 exert effects on the development of recurrent pregnancy loss (RPL) in association with factor V Leiden.

Design And Methods: We determined the EPCR haplotypes A1 and A3 and factor V Leiden in 49 women with a history of RPL and 48 parous controls.

Results: In carriers of factor V Leiden the A1 haplotype decreased the relative risk for RPL from 2.

Association of the protein Z intron F G79A gene polymorphism with recurrent pregnancy loss.

Objective: To investigate the association of the common protein Z (PZ) intron F G79A gene polymorphism with recurrent early pregnancy loss (RPL) and its gene-gene interaction with known thrombophilic risk factors for RPL.

Design: Case control study.

Setting: University clinic.

Epidemiology of haemoglobin disorders in Europe: an overview.

Objective: As a result of global population movements, haemoglobin disorders (thalassaemias and sickle cell disorders) are increasingly common in the formerly non-indigenous countries of Northern and Western Europe and in the indigenous countries of Southern Europe. This article presents an overview of the changing picture and a method for assessing service needs.

Method: Data on country of birth or ethnic origin of residents are adjusted to obtain the estimated proportions of residents and births in non-indigenous groups at risk for haemoglobin disorders in European countries.