Publications by authors named "P Holzner"
Intrahepatic cholangiocarcinoma (iCC) is a rare malignant liver tumor with limited therapeutic advancements. Despite its increasing global incidence knowledge of treatment options remains stagnant, leading to poor five-year patient survival rates and high recurrence post-surgery. ALDH1A1, a member of the ALDH superfamily, is associated with cancer stem cells and has conflicting reports regarding its prognostic role in iCC.
View Article and Find Full Text PDFImmunohistochemical (IHC) studies of formalin-fixed paraffin-embedded (FFPE) samples are a gold standard in oncology for tumor characterization, and the identification of prognostic and predictive markers. However, despite the abundance of archived FFPE samples, their research use is limited due to the labor-intensive nature of IHC on large cohorts. This study aimed to create a high-throughput workflow using modern technologies to facilitate IHC biomarker studies on large patient groups.
View Article and Find Full Text PDFBackground/objectives: Colorectal cancer (CRC) with hepatic (CRLM) and pulmonary metastases (CRLU) presents a significant clinical challenge, leading to poor prognosis. Surgical resection of these metastases remains controversial because of limited evidence supporting its long-term benefits. To evaluate the impact of surgical resection of both hepatic and pulmonary metastases on long-term survival in patients with multivisceral metastatic colorectal cancer, this retrospective cohort study included 192 patients with UICC stage IV CRC treated at a high-volume academic center.
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- The study investigates how partial hepatectomy (pHx), a common surgical procedure for colorectal liver metastasis in Stage IV colorectal cancer (CRC), influences tumor progression at a molecular level using a mouse model.
- Mice that underwent pHx showed significant liver growth and a higher metastatic load compared to control mice, indicating that pHx may enhance the spread of CRC to the liver rather than simply removing existing tumors.
- The findings suggest that pHx triggers inflammatory responses and tissue changes in the liver, creating an environment that promotes the establishment of new metastatic tumors, highlighting the need for a better understanding of post-surgery cancer dynamics.
The management of metastatic hepatocellular carcinoma (HCC) is complex, particularly when complicated by pulmonary embolism. In these cases, atezolizumab-bevacizumab therapy is contraindicated due to an elevated risk of thromboembolic events. Differentiating pulmonary tumor embolism from thromboembolic disease is diagnostically challenging.
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