Publications by authors named "P Hollingworth"
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- Late-onset Alzheimer's disease (LOAD) is the most common type of dementia and is influenced by genetics.
- Researchers studied a lot of people (94,437) to find specific genes that may increase the risk of developing LOAD, confirming 20 known ones and discovering 5 new ones.
- They also found that certain genetic traits related to the immune system and how the brain processes proteins are linked to a higher risk of LOAD, suggesting there are more rare genes yet to be identified that could also play a role.
Article Synopsis
- This study aimed to find new genes linked to late-onset Alzheimer's disease by analyzing a large dataset from the International Genomics of Alzheimer's Project Consortium, which included over 25,000 Alzheimer's patients and around 48,000 controls.
- Researchers discovered new significant genetic loci on chromosomes 8 and 14, expanding the understanding of genetic susceptibility to Alzheimer's beyond previously known genes.
- The newly identified genes are involved in processes related to energy metabolism, protein degradation, and immune response, highlighting potential new targets for therapy in treating Alzheimer's disease.
Patients with muscle disorders can present a diagnostic challenge to physicians because of the different ways they can present and the large number of different underlying causes. Recognition of the 'myopathic phenotype' coupled with investigations usually including electrodiagnostic and histological investigations have been essential for diagnosing the underlying cause of a myopathy. Despite these standard investigations, some patients can remain undiagnosed.
View Article and Find Full Text PDFWe report a very unusual case of a 42-year-old patient with confirmed fibromyalgia and juvenile onset arthritis whose symptoms dramatically improved after surgical excision of a large, dominant hemisphere, parafalcine meningioma.
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