Publications by authors named "P Hogendoorn"
Article Synopsis
- The immune system and vaccine responses differ globally, influenced by geographical, economic, and lifestyle factors, particularly between rural and urban populations.
- A study in Tanzania assessed the immune profiles of 100 healthy individuals, correlating their immune cell types with a lifestyle score derived from living conditions and diet.
- Findings revealed that rural individuals with low lifestyle scores had more activated immune cells, while urban individuals with higher scores had a less activated immune response, suggesting these profiles may affect vaccine responses and relate to lower rates of autoimmunity and allergies in low- and middle-income settings.
Article Synopsis
- Juvenile xanthogranuloma (JXG) is a type of skin tumor mostly found in children, but some cases occur in other parts of the body, and their genetic causes are not fully understood.* -
- A study analyzed 16 children and 5 adults with extracutaneous JXG using advanced sequencing, finding that numerous genetic alterations, especially related to kinase fusions, were present in most children.* -
- The findings indicate that while surgery is common for treatment, some cases can regress on their own, and specific genetic alterations could help inform better treatment options in the future.*
High-grade osteosarcoma, a primary malignant bone tumour, is experiencing a global increase in reported incidence with varied prevalence. Despite advances in management, which include surgery and neoadjuvant chemotherapy often an unsatisfactory outcome is found due to poor or heterogeneous response to chemotherapy. Our study delved into chemotherapy responses in osteosarcoma patients and associated molecular expressions, focusing on CD95 receptor (CD95R), interferon (IFN)-γ, catalase, heat-shock protein (Hsp)70, and vascular endothelial growth factor (VEGF).
View Article and Find Full Text PDFAims: The discovery of somatic genetic alterations established many histiocytic disorders as haematologic neoplasms. We aimed to investigate the demographic characteristics and additional haematologic cancers of patients diagnosed with histiocytic disorders in The Netherlands.
Methods And Results: We retrieved data on histiocytosis patients from the Dutch Nationwide Pathology Databank (Palga).