Publications by authors named "P Hodgkins"
By evaluating published emulations of oncology RCTs studies in which both the active and comparator groups are sourced from RWD and target trial results are available for benchmarking, this systematic review aims to gain insight into factors related to emulation performance. Thirteen oncology emulation studies using various types of RWD were identified through an online database search of PubMed through 2022. Based on the ROBINS-I tool, most studies (N=8) had a serious risk of overall bias driven by risk of bias from confounding.
View Article and Find Full Text PDFArticle Synopsis
- A retrospective cohort study analyzed the effects of remdesivir on hospitalized COVID-19 patients in different countries, focusing on mortality and hospital stay based on oxygen needs.
- The study included 448 patients, revealing that those requiring high-flow oxygen had significantly higher mortality rates (23.6%) and longer hospital stays (13 days) compared to those needing low-flow (10.2% mortality) or no supplemental oxygen (6.2% mortality).
- Timely initiation of remdesivir was crucial, with patients starting treatment more than two days after admission facing a 4.2 times higher risk of death.
Article Synopsis
- Major depressive disorder (MDD) significantly impacts health-related quality of life (HRQoL), and this study examined how the neuroactive steroid zuranolone affects HRQoL using the Short Form-36v2 Health Survey (SF-36v2).
- Adult patients with MDD were randomly assigned to receive either zuranolone or a placebo for two weeks, with HRQoL assessed across various domains at Day 15 showing substantial improvements for those treated with zuranolone, particularly in areas like Mental Health and Vitality.
- The results suggest that zuranolone leads to rapid and meaningful HRQoL enhancements compared to placebo, although the small sample size may limit generalizability and other factors could influence HRQoL
Article Synopsis
- * It involved 295,657 patients with a median age of 66, predominantly male and white, and showed that treatment with remdesivir and corticosteroids significantly increased by December compared to May.
- * Despite high mortality rates in severe cases, the study noted improvements in clinical management and reduced lengths of stay and ICU utilization over the study period.
Community intravenous therapy is well-established in most regions of the UK. Although there are national good practice recommendations detailing the service provision of outpatient parenteral antibiotic therapy (OPAT), examples of extended service delivery of other therapies are limited. This article describes the development of a community IV therapy service through integration with acute and primary care teams.
View Article and Find Full Text PDF