Publications by authors named "P Hirsch"
Introduction: VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic), recently described, due to a somatic mutation of the UBA1 gene and often associated with hemopathy, is characterized by systemic symptoms close to those described in Still's disease or relapsing polychondritis. There are also patients with hemopathy, presenting inflammatory symptoms reminiscent of those of VEXAS syndrome but without mutation of the UBA1 gene.
Case/discussion: Two male patients consulted for general signs, dermatological symptoms, arthralgia, chondritis and venous thrombosis, like patients in the French cohort suffering from VEXAS syndrome.
Plasmids are extrachromosomal DNA molecules in bacteria and archaea, playing critical roles in horizontal gene transfer, antibiotic resistance, and pathogenicity. Since its first release in 2018, our database on plasmids, PLSDB, has significantly grown and enhanced its content and scope. From 34 513 records contained in the 2021 version, PLSDB now hosts 72 360 entries.
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- MiRNAs are a type of non-coding RNA that regulates gene expression and are crucial for various biological pathways, with most studies focused on humans and mice.
- The miRNATissueAtlas has been developed to provide a comprehensive overview of miRNA expression across different tissues in both Homo sapiens and Mus musculus, now incorporating significantly more data and samples in its latest release.
- The 2025 update features expression data from 799 billion reads across 61,593 samples, an increase in the variety of tissues studied, and new calculations that enhance the understanding of tissue specificity and cross-species comparisons.
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- Benthic fish like the round goby swim close to the bottom, particularly in fast-moving water, and researchers aimed to investigate if this offers them a hydraulic advantage based on their position and substrate type.
- Experiments measured the hydraulic forces on preserved fish at different heights above smooth and rough surfaces in a flow channel, finding no significant difference in forces at the bottom, but higher forces in the water column above rough surfaces.
- A convolutional neural network analysis indicated that the fish's body posture and movements play a more critical role in the forces they experience than their height in the water, leading to discussions about why they prefer swimming near the bottom.
Dual tasks are a common phenomenon in everyday life. In dual-task contexts, we perform two-component tasks in temporal overlap, which usually results in impaired performance in one or both of these component tasks relative to single-task contexts. Numerous studies have examined dual-task interference at the level of response selection, but only a few studies have addressed the cognitive representation of a dual task and the cognitive mechanisms controlling these representations.
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