Publications by authors named "P Hickman"
Background: Switching from a conventional to a high-sensitivity cardiac troponin (hs-cTn) assay enables detection of smaller amounts of myocardial damage, but the clinical benefit is unclear. We investigated whether switching to a hs-cTnI assay with a sex-specific 99th centile diagnostic threshold was associated with lower 1-year death or new myocardial infarction (MI) in patients with suspected acute coronary syndrome (ACS).
Methods: This pre-post study included nine tertiary hospitals in Australia.
, the pale cyst nematode (PCN), is a quarantine pest of potato posing a serious threat to the Idaho potato industry. only hatches in the presence of a hatching stimulus produced by a host plant or closely related species. In the absence of this hatching stimulus, can remain viable in the soil for decades.
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- Metastatic castration-resistant prostate cancer (mCRPC) is a severe form of cancer that often leads to poor patient outcomes, prompting the need for better treatment options.
- Researchers developed and characterized three new patient-derived tumor xenograft (PDTX) models to explore the effectiveness of combining CDK4/6 inhibitors with AKT inhibitors, using 3D spheroids to study drug resistance patterns.
- Findings indicated that the combination therapy showed promising results in overcoming resistance to single-agent treatments, which supports future clinical trials for mCRPC patients with specific genetic profiles.