Towards a Responsive, Sustainable and Collaborative Model of Care at Toronto's Michael Garron Hospital.

In 2008, Michael Garron Hospital, transformed its approach to care delivery. The rationale: to improve quality, increase safety and boost patient and staff engagement and satisfaction. The Coordinated Care Team (CCT) model has enabled nurses to not only work to their full scopes of practice within a team of interprofessional providers and unlicensed staff, but also helped create a culture of safety and patient-centredness in a value-driven context.

[Generic medications and prescription by non-proprietary name].

Complementarily to a previous publication, this paper tries to answer a few commonly asked questions about--generic medications: pharmaceutical quality, bioequivalence and therapeutic equivalence, substitution, etc. A summary of recent regulations about reference price and prescription by non-proprietary name, aiming at the promotion of generic medication prescription is also presented.

Determination of meprobamate in pharmaceutical dosage forms also containing carbromal by liquid chromatography and indirect photometric detection.

In a pharmaceutical form also containing carbromal, meprobamate could not be quantified selectively by classical methods described in pharmacopoeias due to a significant interference from carbromal. Consequently, reversed-phase HPLC methods have been developed to separate the two active ingredients using indirect photometric detection to visualize and determine meprobamate which has very poor chromophoric properties. Different parameters influencing the sensitivity of the indirect response, such as the nature of the highly absorbing compound added to the mobile phase (the marker) as well as the methanol content and the pH of this phase, have been studied.

Influence of pregnancy on human immunodeficiency virus disease.

Over a period of 3 years (mean 16, extremes 3 and 36 months), we compared clinical and laboratory parameters of 128 female, human immunodeficiency virus (HIV)-infected patients, all in clinical stage II or III (CDC classification). 34 patients were pregnant and delivered a viable infant after at least 28 weeks of amenorrhea (group I), 29 patients were pregnant and had a spontaneous or induced abortion during the first or second trimester (group II), and 64 were non-pregnant female control patients (group III). The changes in the clinical stages over time were not statistically significant between the groups.

[Indirect spectrophotometric detection by reversed-phase liquid chromatography. Application in drug analysis].

By inclusion of a high U.V. or visible-absorbing component to the mobile phase of a RP-HPLC system, it is possible, after they were separated by chromatography, to detect indirectly and to quantify analytes which do not themselves absorb at the detection wavelength.