Publications by authors named "P Hernandez-Jimenez"
Prosthetic joint infections are considered difficult to treat they needing aggressive surgery and long antimicrobial treatments. However, the exact duration of these therapies has been established empirically. In the last years, several studies have explored the possibility of reducing the length of treatment in this setting, with conflicting results.
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- The study aimed to determine whether OXA-48 carbapenemase production affects the outcome of Klebsiella pneumoniae infections after adjusting for clinical factors.
- It involved comparing 117 cases of infections caused by OXA-48-producing strains with 117 cases from non-OXA-48 strains, focusing on clinical cure rates and mortality.
- Results indicated that OXA-48 strains were linked to significantly lower clinical cure rates and higher 30-day mortality, establishing OXA-48 production as an independent risk factor for poor outcomes in infections.
Background: Pseudomonas aeruginosa (PSA) infection often occurs in immunocompromised patients, which also face an increased risk of multidrug-resistant (MDR) bacteria. A deeper knowledge of the risk factors for MDR-PSA infection in this patient population may help to choose appropriate empirical antibiotic therapy. Methods: a single-center case-control (1:2) retrospective study that included 48 patients with underlying immunosuppression developing MDR-PSA infection (cases) and 96 patients also immunocompromised that were infected with non-MDR-PSA (controls) was conducted.
View Article and Find Full Text PDFObjectives: Multidrug-resistant Pseudomonas aeruginosa (MDR-PSA) constitutes an emerging health problem. A predictive score of MDR-PSA infection would allow an early adaptation of empirical antibiotic therapy.
Methods: We performed a single-centre case-control (1:2) retrospective study including 100 patients with MDR-PSA and 200 with a non-MDR-PSA infection.
Objectives: To describe the determinants of outcome of infections due to oxacillinase-48 (OXA-48) carbapenemase-producing Klebsiella pneumoniae (OXA-48-Kp).
Methods: A retrospective cohort study of 117 episodes of OXA-48-Kp infection were conducted. Multivariate Cox models identified factors predicting 14-day clinical response and 30-day all-cause mortality.