Publications by authors named "P Henson"
Article Synopsis
- Chronic Granulomatous Disease (CGD) is characterized by sterile pyogranulomas and increased cytokine production, indicating hyperinflammation.
- Research using zymosan-treated CGD and wild-type mice revealed that CGD cells form aggregates of neutrophils and monocyte-derived macrophages (MoMacs), driven by LTB signaling and CD11b expression.
- Disruption of CD11b in CGD mice led to poorly organized pyogranulomas and decreased inflammatory cytokine production, highlighting the importance of neutrophil aggregation in the inflammatory response.
Introduction: Loss of NADPH oxidase activity results in proinflammatory macrophages that contribute to hyperinflammation in Chronic Granulomatous Disease (CGD). Previously, it was shown in a zymosan-induced peritonitis model that gp91 (CGD) monocyte-derived macrophages (MoMacs) fail to phenotypically mature into pro-resolving MoMacs characteristic of wild type (WT) but retain the ability to do so when placed in the WT milieu. Accordingly, it was hypothesized that soluble factor(s) in the CGD milieu thwart appropriate programming.
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- The study examines diversity in physical medicine and rehabilitation residencies in the US, highlighting the need for the medical field to reflect the country's growing population diversity.
- A survey sent to program directors revealed that the percentage of women and underrepresented minorities in these residencies is lower than in the general US population.
- The presence of departmental roles focused on diversity, equity, and inclusion was linked to a higher percentage of women residents, but no significant correlation was found between diversity recruitment strategies and the presence of underrepresented minority residents.
Introduction: Studies finding perioperative hyperglycaemia is associated with adverse patient outcomes in surgical procedures spurred the development of blood glucose guidelines at many institutions. In this trial, we will assess the implementation of a clinical decision support tool that is integrated into the intraoperative portion of our electronic health record and provides real-time best practice recommendations for intraoperative insulin dosing in surgical patients at high risk for hyperglycaemia.
Methods And Design: We will assess this intervention using a sequential and repeated cross-over design at the institutional level with periods of time for wash-out, control and study intervention.