Publications by authors named "P Heimann"
Background: Synchronous malignant histiocytoses are rare conditions that occur concurrently with another hematologic neoplasm. Most reported cases are associated with B-cell lymphoproliferative disorders, while associations with T-cell hemopathies are less common. These two diseases may share mutations and/or cytogenetic anomalies, which can lead to malignant proliferations.
View Article and Find Full Text PDFMeasurable residual disease assessment prior to allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia and myelodysplastic syndromes: a 20-year monocentric study.
Ann Hematol
November 2024
Article Synopsis
- * A study of 192 patients revealed that MRD-negative patients had significantly better overall survival, disease-free survival, and lower relapse rates compared to MRD-positive patients, with specific MRD testing methods like multiparametric flow cytometry (MFC) and PCR contributing to these findings.
- * The prognosis of MRD-positive patients varied by factors such as age and type of cancer, particularly showing lower disease-free survival in younger AML patients
Article Synopsis
- The study investigates the local structure and physical properties of molten silicates under extreme conditions, which are important for understanding planetary evolution.
- Researchers used advanced techniques like in situ X-ray diffraction and high-power lasers to analyze shock-compressed liquid silicates with varying iron content at extremely high pressures.
- Findings suggest that the densification of silicate networks continues beyond pressures found in Earth's interior, potentially affecting the formation and differentiation of rocky planets and super-Earths.
Glioblastoma, the most common and lethal primary adult brain tumor, cannot be successfully removed surgically due to its highly invasive nature. Therapeutically, approaches must be aimed at a systemic brain disease and not merely at a tumor located within the brain, unless a successful containment strategy can be found. Reelin, an extracellular matrix glycoprotein, plays an important role in neuronal migration and serves here as a natural stop signal.
View Article and Find Full Text PDFIntense x-ray pulses can cause the non-thermal structural transformation of diamond. At the SACLA XFEL facility, pump x-ray pulses triggered this phase transition, and probe x-ray pulses produced diffraction patterns. Time delays were observed from 0 to 250 fs, and the x-ray dose varied from 0.
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