Publications by authors named "P Hecht"
Risankizumab Efficacy and Safety Based on Prior Inadequate Response or Intolerance to Advanced Therapy: Post Hoc Analysis of the INSPIRE and COMMAND Phase 3 Studies.
Remo Panaccione Edouard Louis Jean-Frederic Colombel Geert D'Haens Laurent Peyrin-Biroulet Patrick M Hecht
J Crohns Colitis
January 2025
Background And Aims: Treating ulcerative colitis (UC) in patients with prior advanced therapy (AT) exposure may be challenging. We report the efficacy and safety of risankizumab, a monoclonal interleukin 23p19 antibody, in patients with UC and prior inadequate response or intolerance to AT (AT-IR).
Methods: In the 12-week phase 3 INSPIRE induction study, patients were randomized to intravenous risankizumab 1200 mg or placebo.
Article Synopsis
- The W.H.O. fungal priority pathogen requires better tools for studying essential genes, and the auxin-inducible degron (AID) system offers a solution for rapidly depleting proteins.
- The AID2 system enhances previous methods by using a specific auxin (5-Ph-IAA) and a mutant version of OsTIR1 to increase sensitivity and effectiveness in protein degradation.
- Researchers optimized the AID2 system for their studies, proving it can effectively target and degrade essential proteins, thus allowing for deeper exploration of the genome's functionality.
Article Synopsis
- More severe forms of atopic dermatitis and psoriasis significantly impact quality of life, lead to higher healthcare costs, and are linked to other health issues; addressing these problems early can help lessen the burden.
- The BIOMAP consortium is a large-scale research initiative that compiles clinical and molecular data from various studies to improve the understanding of disease severity and identify reliable biomarkers.
- The consortium emphasizes the importance of using consistent definitions for disease severity and considers various factors when analyzing data to ensure that findings are relevant to both patients and healthcare practitioners.
Article Synopsis
- - The study investigates the relationship between stress exposure and dietary omega-3 fatty acid intake in the context of Alzheimer's disease (AD) risk.
- - Results show that higher omega-3 intake is linked to healthier individuals with significant stress, whereas no difference was noted at lower stress levels among AD patients.
- - Findings suggest omega-3 fatty acids could help reduce AD risk when stress levels are high, necessitating further research with larger groups to explore these interactions.
Article Synopsis
- Environmental and genetic factors play a role in autism spectrum disorder (ASD), with particular emphasis on maternal stress during pregnancy and its potential impact on the likelihood of having a child with ASD.
- An exploratory study assessed the relationship between maternal antibodies, prenatal stress levels, and ASD diagnosis in children by analyzing blood samples from 53 mothers with at least one child with ASD.
- Findings showed no significant correlation between maternal stress and antibody presence, suggesting that although both factors are linked to ASD, they may operate independently rather than through a shared mechanism, warranting further investigation with a larger sample size.