Publications by authors named "P Hanna C Corre"
Background: Dental implantation of bone reconstructions in oncologic situations improves patients' orofacial function and quality of life. There are currently no recommendations on the timing of implantation.
Methods: This systematic review with meta-analysis aimed to compare primary and secondary dental implantation of free bone flaps in reconstructions for malignant tumors of the oral cavity.
Ossifying fibroma (OF) is a rare benign fibro-osseous neoplasm developing mostly in maxillo-facial bones. OF is divided in cemento-ossifying fibroma (COF), juvenile trabecular ossifying fibroma (JTOF) and psammomatoid ossifying fibroma (PSOF). The aim of this systematic review was to synthetize the existing literature on OF, investigating the clinical and radiological parameters related to the different forms of the disease, and to compare the treatment modalities according to their associated recurrence rate.
View Article and Find Full Text PDFMeasurement of Cumulative Drug Exposure from Clinical Data Warehouse.
Stud Health Technol Inform
November 2024
Polypharmacy (PP) and hyperpolypharmacy (HPP), are prevalent among cancer patients and are associated with an increased risk of drug-drug interactions (DDI) and potentially inappropriate medications (PIM). This study aimed to characterize PP, HPP, DDI, and PIM in patients with hematological malignancies hospitalized for hematopoietic stem cell transplantation (HSCT) by introducing a novel metric: cumulative drug exposure. Clinical data warehouse (CDW) records were employed to develop algorithms that quantified patients' cumulative exposure to these prescribing determinants during hospitalization.
View Article and Find Full Text PDFArticle Synopsis
- * In mice with mutations in ciliary proteins, abnormal cranial neural crest-derived cells disrupt signaling pathways, leading to improper cell differentiation and subsequent tongue issues like ankyloglossia.
- * The research also indicates that these tongue deformities can be artificially triggered in normal mice, suggesting potential avenues for treatment approaches in ciliopathies.
Article Synopsis
- Graft-versus-host disease (GVHd) poses a challenge after allogeneic hematopoietic stem cell transplantation (HSCT), with ciclosporin used for prevention but showing complex variations in metabolism due to factors like inflammation.
- A study involving 71 adult HSCT patients assessed the relationship between inflammation levels (measured by C-reactive protein) and ciclosporin metabolism, finding that severe inflammation led to decreased metabolism but did not affect blood levels thanks to dose adjustments.
- The study concluded that inflammation significantly impacts ciclosporin pharmacokinetics, emphasizing the need for careful therapeutic monitoring and potential personalized dosage strategies in HSCT patients.