Publications by authors named "P Halle"
Background: The treatment of relapsed or refractory leukemia remains a major problem. Among the new therapeutic approaches, the use of modified T lymphocytes, called chimeric antigen receptor T cells (CAR-T cells), seems promising. The first step of their preparation is leukapheresis, which involves the collection of mononuclear cells from the patient.
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- This study compared high-volume (2 L + 2 L) polyethylene glycol (PEG) bowel preparation with low-volume (1 L + 1 L) PEG combined with bisacodyl in adult patients undergoing colonoscopy.
- Results showed that low-volume preparation was just as effective as high-volume in achieving adequate bowel cleansing, with 90.1% success vs. 88.1% for high-volume, although patients reported fewer symptoms and were more willing to repeat the process.
- The findings suggest that low-volume PEG is a better option for bowel preparation due to its tolerability, while high-volume preparation had slightly better procedural outcomes but caused more discomfort.
Hematopoietic progenitor cells-apheresis (HPC-A) collection is now a routine procedure for autologous hematopoietic stem cell transplantation. Here we present our 25 years' experience of HPC-A collection in children weighing 8 kg or less, with a focus on the evolution of our standard operating procedures, and the safety limits for these young patients, in the Pediatric Apheresis Unit of Clermont-Ferrand University Hospital (France). Fifteen children weighing 8 kg or less underwent 26 HPC-A collections over 25 years.
View Article and Find Full Text PDFIntroduction: Bowel cleanliness has been shown to be superior with split-dose vs nonsplit preparations; we aimed to directly assess the poorly characterized comparative efficacies of split-dose vs same-day polyethylene glycol (PEG) regimens.
Methods: In this study, one of a series of randomized trials performed across 10 Canadian endoscopy units, patients undergoing colonoscopies between 10:30 and 16:30 were allocated to PEG low-volume same-day (15 mg bisacodyl the day before, 2 L the morning of the procedure), low-volume split-dose (15 mg bisacodyl the day before, 1 L + 1 L), or high-volume split-dose (2 L + 2 L). Coprimary endpoints were adequate bowel cleansing based on the Boston Bowel Preparation Scale using in turn different threshold cutoffs.
Article Synopsis
- - Ewing sarcoma (EWS) is a serious pediatric cancer that can metastasize, and to protect fertility, doctors often suggest freezing ovarian or testicular tissue before treatment.
- - A study aimed to establish a reliable method for detecting minimal residual disease (MRD) from EWS in frozen reproductive tissues, finding a strong correlation between tumor cell numbers and specific transcript levels using RT-qPCR.
- - Results showed that while contaminated samples tested positive for tumor markers, no MRD was detected in samples from children with EWS, confirming RT-qPCR's accuracy for monitoring EWS in reproductive tissues.