Publications by authors named "P Habibovic"
Doxorubicin (Dox) is a promising anticancer chemotherapeutic, which has been widely investigated in osteosarcoma (OS) treatment. However, there are several disadvantages regarding its clinical use. Specifically, Dox has low specificity toward cancer cells, which can lead to serious side effects.
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- The extracellular matrix (ECM) is crucial for tissue regeneration, and researchers are interested in developing hydrogels that mimic its dynamic and fibrous structure for regenerative medicine.
- A new hybrid hydrogel network was created by combining supramolecular assemblies with covalent crosslinkers made from mesoporous silica nanoparticles (MSNs) and functionalized macromonomers, enhancing the mechanical properties.
- The resulting NBTA-MSN nanocomposites showed improved structural stability, elasticity, self-healing, injectability, and good cytocompatibility, along with the ability to serve as calcium and phosphate ion reservoirs, making them promising materials for various applications.
Bioactive glasses (BGs) belong to a group of ceramic biomaterials having numerous applications due to their excellent biocompatibility and bioactivity. Depending on their composition, properties of BGs can be finely tuned. In this study, we investigated both angiogenic and osteogenic properties of a novel family of BGs from the SiO-CaO-NaO system.
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- - This study explores a novel method for creating vascular networks in 3D microtissues using microwell arrays made from thin polymer films, which can be non-porous or porous.
- - The researchers use two different configurations for cultivating endothelial cells: one with cells growing inside non-porous wells and another with cells on the outside of porous wells, allowing them to sprout inward.
- - The results successfully demonstrate vascularization in spheroids made from human stem cells and osteosarcoma cells, indicating that these methods can generate robust vascular networks needed for functional tissue engineering.
Enthesitis, the inflammation of the enthesis, which is the point of attachment of tendons and ligaments to bones, is a common musculoskeletal disease. The inflammation often originates from the fibrocartilage region of the enthesis as a consequence of mechanical overuse or -load and consequently tissue damage. During enthesitis, waves of inflammatory cytokines propagate in(to) the fibrocartilage, resulting in detrimental, heterotopic bone formation.
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