Publications by authors named "P H Vishnu"
Article Synopsis
- The study evaluates the diagnostic significance of two immunoassay tests for heparin-induced thrombocytopenia (HIT) using data from 1393 patients, aiming to clarify the reliability of test results across their ranges.
- Findings reveal that while both assays correlate results to HIT diagnoses, the strength of this correlation differs, with the CLIA method showing a more pronounced increase in likelihood ratios compared to the ELISA method.
- A web-based calculator is provided to help clinicians estimate the probability of HIT based on individual test results, enhancing decision-making in patient care.
Renal cell carcinoma (RCC) is the most common solid tumor in the kidney (90%), accounting for about 3% of all cancers in adults. Partial nephrectomy (PN) is the surgical procedure primarily used for the treatment of localized kidney tumors. Two commonly used terms to describe the complexity and success of a partial nephrectomy procedure are "trifecta" and "pentafecta.
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- New analytical techniques allow for the simultaneous assessment of hundreds of proteins, helping to understand their roles in diseases like heparin-induced thrombocytopenia (HIT).
- Researchers used four panels of the Olink proximity extension assay on patients suspected of HIT to identify potential new biomarkers related to thrombus formation, inflammation, and the immune response.
- The study indicated that soluble P-selectin could serve as a significant marker for HIT, with future research planned to evaluate its diagnostic and prognostic value in patient care.
Importance: Heparin-induced thrombocytopenia (HIT) is a life-threatening condition that requires urgent diagnostic clarification. However, knowledge of the diagnostic utility of the recommended diagnostic tests is limited in clinical practice.
Objective: To evaluate the current diagnostic practice for managing the suspicion of HIT.
Article Synopsis
- The study investigates the correlation between three different tests for diagnosing heparin-induced thrombocytopenia (HIT) in a cohort of 1393 patients, revealing weak correlations among the tests used.
- Only 8.5% (119 patients) were classified as HIT-positive, with notable differences in 4Ts scoring between HIT-positive and HIT-negative patients.
- The inconsistent results suggested a need for standardizing these antibody assays to improve their accuracy and comparability in clinical practice.