Publications by authors named "P H Van der Kroon"
Article Synopsis
- HIV-1 modifies tetraspanins like CD9 to enhance its entry and replication within host cells, highlighting CD9's important role during infection.
- Researchers created specialized nanobodies from llamas that target CD9, discovering several that bind effectively and have potential in combatting HIV-1.
- These nanobodies didn't stop the initial virus lifecycle but were successful in preventing fusion of infected cells and reducing HIV-1 replication in immune cells, suggesting new treatment options alongside current antiretrovirals.
Background And Purpose: Brachytherapy is treatment of choice for early stage nasal vestibule cancer. Over the years improvements were achieved by means of image guided target definition, interstitial implant techniques and also individual mold techniques. The aim of this study was to improve the technique of the implant so that the need for interstitial catheters can be limited by making use of patient individualized 3D-printed applicators.
View Article and Find Full Text PDFAdaptive brachytherapy for cervical cancer in combined 1.5 T MR/HDR suite: Impact of repeated imaging.
Tech Innov Patient Support Radiat Oncol
September 2024
Introduction: At our department we have a dedicated 1.5 Tesla MRI/HDR brachytherapy suite, which provides the possibility of repeated MRI scanning before, during and after applicator insertion and before and/or after irradiation for patients with advanced cervical cancer. In this study we analysed the effect of this adaptive workflow.
View Article and Find Full Text PDFEvaluation of the effect of RNA secondary structure on Cas13d-mediated target RNA cleavage.
Mol Ther Nucleic Acids
September 2024
The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas13d system was adapted as a powerful tool for targeting viral RNA sequences, making it a promising approach for antiviral strategies. Understanding the influence of template RNA structure on Cas13d binding and cleavage efficiency is crucial for optimizing its therapeutic potential. In this study, we investigated the effect of local RNA secondary structure on Cas13d activity.
View Article and Find Full Text PDFBackground: Older subjects are at risk of elevated intestinal permeability (IP) which can lead to immune system activation and low-grade systemic inflammation. Dietary changes are a potential strategy to reduce IP. The MaPLE project evaluated the hypothesis that increasing (poly)phenol intake would beneficially impact on several important markers and pathways related to IP.
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