Publications by authors named "P H Thuong"
Oxidative stress induced by glutamate is a significant contributor to neuronal cell damage and can lead to neurodegenerative diseases such as Alzheimer's, Huntington's, and ischemic brain injury. At the cellular level, oxidative stress increases Ca ion influx and reactive oxygen species (ROS), which activate the MAPK signaling pathway. Additionally, the generation of ROS causes mitochondrial dysfunction, triggering apoptosis by promoting the translocation of AIF to the nucleus from the mitochondria.
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- - The study analyzed six solvent fractions from ethanolic extracts of flower buds and leaves for their phytochemical contents and antioxidant activities, revealing that the flower bud aqueous fraction (BAF) had the highest phenolic content and antioxidant capacity.
- - The flower bud hexane fraction (BHF) and leaf hexane fraction (LHF) showed notable antibacterial properties, particularly against specific bacterial strains, with DMC from BHF exhibiting even stronger antibacterial activity than the fractions.
- - DMC demonstrated significant inhibitory effects on urease and α-amylase but no effect on α-glucosidase, suggesting potential for developing natural treatments for gastric infections with minimal toxicity to human cells.
Article Synopsis
- Vietnamese ginseng (Panax vietnamensis) is well-known for its medicinal properties, particularly due to bioactive compounds called ginsenosides found mainly in its rhizome.
- A recent study identified seven ginsenosides in the leaves of Vietnamese ginseng, notably ginsenoside Rd and pseudoginsenoside RS1, which showed significant inhibition of the enzyme acetylcholinesterase, important for memory function.
- The research suggests that the leaves could be an alternative source for enhancing memory, providing a basis for further exploration into their potential anti-dementia benefits.
Background: Adolescent pregnancy is a global issue. The majority of these adolescents experience unintended pregnancy ending in abortion. Knowledge gaps and misconceptions about reproductive health are the main reasons for unintended pregnancy among adolescents.
View Article and Find Full Text PDFIntroduction: It is assumed that host defense systems eliminating the pathogen and regulating tissue damage make a strong impact on the outcome of tuberculosis (TB) disease and that these processes are affected by rifampicin (RIF) resistance-conferring mutations of (Mtb). However, the host responses to the pathogen harboring different mutations have not been studied comprehensively in clinical settings. We analyzed clinico-epidemiological factors and blood transcriptomic signatures associated with major mutations conferring RIF resistance in a cohort study.
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