Diathermy loop excision in the management of cervical intraepithelial neoplasia: diagnosis and treatment in one procedure.

Objective: Diathermy loop excision was performed as a new diagnostic-treatment in patients with cervical cytologic diagnoses consistent with an epithelial abnormality.

Study Design: A total of 424 patients with cervical cytologic diagnoses consistent with an epithelial abnormality, but macroscopically or colposcopically not consistent with invasive carcinoma, were subjected to diathermy loop excision to diagnose and treat cervical lesions in one procedure.

Results: The diagnostic accuracy rate was 99%.

[Refocusing on the gynecological and obstetrical consequences of intrauterine exposure to diethylstilbestrol (DES)].

The oncological and obstetrical follow-up is described of 321 patients who presented between 1981 and 1988 in the St Radboud Hospital with a history of intrauterine diethylstilbestrol(DES) exposure. In 45 out of 321 cases cytological abnormalities were found including 20 cases of cervical intraepithelial neoplasia (CIN). No relation could be established between CIN and the extension of the cervical adenosis.

Scanning electron microscopy of exfoliative cervical cytology.

The cervical epithelium was studied in 2260 cells with the consecutive LM-SEM method. The purpose of the study was to describe as many cell types as possible and compare these results with the literature. Cells should be related to two diagnoses: that of the individual cell, and that of the tissue from which it originates.

Cell surface morphology in epithelial malignancy and its precursor lesions.

The cell surface organization of cancer cells is of potentially great significance, as it may not only allow (early) diagnosis, but as it may also harbour markers for refined prognosis (degree of oncogenetic and metastatic potential), and targets for selective cancer (chemo- and immuno) therapy. With these aspects in mind, the present review deals with SEM work done on (pre-) malignant cells, both in vivo and in vitro, and in animal models. Attention, however, is focused on human cancer cells.