Publications by authors named "P H Sheridan"
Surgical cutting with electrosurgical tools facilitates tissue dissection and vessel sealing, preventing blood loss. The extent of tissue necrosis due to temperature elevations is dependent on the cutting technique, device design, coating properties and power settings, but the influence of these parameters is not fully understood. Here we conduct a comprehensive comparative analysis of thermal damage comparing (1) manual user-controlled and robotic electrosurgical cutting approaches for (2) varying electrodes and coatings, and power settings.
View Article and Find Full Text PDFBackground: Dietary quality has been linked to better glycemic control, but the precise molecular mechanisms giving rise to these associations are not fully understood.
Objectives: To examine the association of metabolites associated with the intake of a healthy diet with measures of insulin/glucose homeostasis.
Methods: Using cross-sectional data from 295 United States adults, the associations between 3 diet pattern scores and metabolome-wide metabolites were estimated via linear regression models, which controlled for demographic factors and health behaviors.
Microbes drive fundamental ecosystem processes, such as decomposition. Environmental stressors are known to affect microbes, their fitness, and the ecosystem functions that they perform; yet, understanding the causal mechanisms behind this influence has been difficult. We used leaf litter on soil surface as a model in situ system to assess changes in bacterial genomic traits and decomposition rates for 18 months with drought as a stressor.
View Article and Find Full Text PDFArticle Synopsis
- The human gut microbiota is crucial for health, with specific families like Lachnospiraceae and Oscillospiraceae often lacking in disease conditions, yet they're not well-represented in lab cultures.
- This study introduces a new culturomics platform that uses a simple growth medium combined with MALDI-TOF MS technology to quickly isolate and identify many gut bacteria, successfully cultivating 724 unique isolates from just 11 fecal samples.
- The research also developed a new database, MaldiGut, that enhances bacterial identification by providing profiles for various species, thus facilitating further investigation of these important but underexplored microbial families.
Article Synopsis
- Phylogenetic reconciliation is a method used to study how gene trees evolve in relation to species trees, helping to explain changes through events like gene duplications and losses.
- This approach is beneficial for understanding genome evolution, aiding in tasks such as inferring ancestral gene content and analyzing metabolic evolution across microbial lineages.
- There are many opportunities to expand this method in microbiology, including improving models for realism, scalability, and integrating ecological factors to enhance our understanding of microbial diversity.