Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years.

Competition for respiration between substrates in animal tissues has been known for at least 80 years. The most important interaction, quantitatively is between glucose and fatty acids. The starting point in 1963 for the so called Glucose Fatty Acid Cycle was the realisation that the metabolic relationship between glucose and fatty acids is reciprocal and not dependent.

Fasting and decreased B cell sensitivity: important role for fatty acid-induced inhibition of PDH activity.

Fasting inhibits glucose-induced insulin secretion. We investigated the role of a glucose fatty acid cycle for such inhibition and its molecular basis in pancreatic islets from 48-h fasted rats. The fasting-impaired insulin response to 27 mM glucose was restored by 41% with a carnitine palmitoyltransferase I inhibitor, etomoxir.

Spatial distribution of naturally occurring 210Po and 226Ra in children's teeth.

Deciduous and permanent teeth extracted from juveniles for orthodontic purposes have been analysed using alpha-sensitive plastic track detectors for the spatial distribution of total alpha-activity and naturally occurring 210Pb-supported 210Po and 226Ra. The distribution of these radionuclides is non-uniform, with 210Po being primarily associated with outer enamel and 226Ra with the pulp. The observations suggest that 210Pb/210Po concentrates at the interface of enamel with saliva or blood, by means of unidirectional ionic exchange with calcium.