Publications by authors named "P H P Van Hamersveld"
Innervation of the intestinal mucosa by the sympathetic nervous system is well described but the effects of adrenergic receptor stimulation on the intestinal epithelium remain equivocal. We therefore investigated the effect of sympathetic neuronal activation on intestinal cells in mouse models and organoid cultures, to identify the molecular routes involved. Using publicly available single-cell RNA sequencing datasets we show that the α isoform is the most abundant adrenergic receptor in small intestinal epithelial cells.
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- Vagus nerve stimulation (SpNS) was tested in mice to see if it could reduce inflammation in inflammatory bowel disease (IBD) by targeting the splenic nerve and releasing norepinephrine (NE).
- Mice received stimulation during an induced colitis experiment, showing improved symptoms and lower inflammation markers compared to those with no stimulation.
- The results suggest SpNS may lower immune response activation, indicating potential for clinical application in IBD treatment for humans.
Article Synopsis
- * A study analyzed fecal samples from 31 UC patients and 7 donors to determine which fungal species are linked to improved clinical outcomes following FMT.
- * The findings suggest that certain yeast species in donor feces correlate with successful FMT outcomes, indicating the potential for these fungi to serve as biomarkers for predicting treatment success in UC patients.
Background: Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease affecting the intra- and extrahepatic bile ducts, and is strongly associated with ulcerative colitis (UC). In this study, we explored the peripheral blood DNA methylome and its immune cell composition in patients with PSC-UC, UC, and healthy controls (HC) with the aim to develop a predictive assay in distinguishing patients with PSC-UC from those with UC alone.
Methods: The peripheral blood DNA methylome of male patients with PSC and concomitant UC, UC and HCs was profiled using the Illumina HumanMethylation Infinium EPIC BeadChip (850K) array.
Article Synopsis
- Antimicrobial responses are crucial for gut health, and the study focuses on how miR-511 affects TLR4 responses, leading to increased intestinal inflammation.
- Mice lacking miR-511 showed less severe colitis symptoms and lower inflammatory cytokine levels compared to normal mice when exposed to DSS, indicating a protective role against intestinal inflammation.
- The research also identified Wdfy1 as a target of miR-511, suggesting that diminished WDFY1 levels in miR-511-deficient macrophages contribute to reduced immune responses from TLR3 and TLR4.