Spontaneous Extradural Hematoma in a Sickle Cell Anemia Patient with Hyperinflammation and Thrombotic Microangiopathy Successfully Treated with Eculizumab: A Case Report and Review of the Literature.

Background:  The event of extradural hematoma in the absence of head trauma is a rare central nervous system complication of sickle cell disease. We report here a case of spontaneous extradural hematoma in a patient being treated for sickle cell vasoocclusive crisis complicated by hyperinflammation and thrombotic microangiopathy. The significance of inflammation as an integral component of the pathomechanism of vasoocclusive crisis in patients with sickle cell disease and the role of heme in activating the complement system's alternative pathway are highlighted in this case report.

Per- and poly-fluoroalkyl substances in commercial organic eggs via fishmeal in feed.

Chicken eggs can be a significant source of human PFAS exposure. A survey of PFAS in commercial eggs from larger farms across Denmark showed the absence or low contents of PFAS in free-range and barn eggs. However, organic eggs from eight farms collected in September 2022 had a similar profile of nine PFASs with a predominance of odd over even carbon length PFCAs.

Using random forest machine learning on data from a large, representative cohort of the general population improves clinical spirometry references.

Introduction: Spirometry is associated with several diagnostic difficulties, and as a result, misdiagnosis of chronic obstructive pulmonary disease (COPD) occurs. This study aims to investigate how random forest (RF) can be used to improve the existing clinical FVC and FEV1 reference values in a large and representative cohort of the general population of the US without known lung disease.

Materials And Methods: FVC, FEV1, body measures, and demographic data from 23 433 people were extracted from NHANES.

Status and perspectives of biomarker validation for diagnosis, stratification, and treatment.

Objectives: The aim of this study was to discuss the status of and perspective for biomarker validation in view of the challenges imposed on national healthcare systems due to an increasing number of citizens with chronic diseases and new expensive drugs with effects that are sometimes poorly documented. The demand for a paradigm shift toward stratification of patients or even 'personalized medicine' (PM) is rising, and the implementation of such novel strategies has the potential to increase patient outcomes and cost efficiency of treatments. The implementation of PM depends on relevant and reliable biomarkers correlated to disease states, prognosis, or effect of treatment.

Outpatient vs inpatient total laparoscopic hysterectomy: A randomized controlled trial.

Introduction: The objective of the study was to investigate whether outpatient total laparoscopic hysterectomy (TLH) could be performed as a routine without compromising patient satisfaction. The main outcomes were patient satisfaction with length of hospital stay, quality of life, complications and readmissions, and time to return to work.

Material And Methods: A non-blinded prospective randomized controlled trial (Canadian Task Force classification I) performed in a single-center teaching hospital in Denmark.