Publications by authors named "P H O'Donnell"

Background: Cancer patients frequently suffer from pain, often managed with opioids. However, undertreated pain remains a significant concern. Opioid effectiveness varies due to genetic differences in how individuals metabolize some of these medications.

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Background: Social prescribing link workers support patients to connect with community resources to improve their health and well-being. These roles are prominent in policy, but there is limited evidence on what support is provided by link workers and what factors influence implementation of link worker interventions.

Methods: A convergent, mixed methods process evaluation of an exploratory randomised trial of a one-month general practice-based link worker intervention targeting adults with multimorbidity in deprived areas.

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Article Synopsis
  • The ESSR updated its 2015 consensus on soft tissue tumor imaging due to advancements in technology and updated classifications.
  • A panel of 46 radiologists from 12 European countries used a validated Delphi method to reach consensus on imaging strategies, resulting in high agreement on 47 statements.
  • Key findings highlight that MRI is preferred for monitoring soft tissue sarcomas, with chest CT recommended for assessing metastasis and interventional radiology playing a role in treating specific cases.
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Widespread distribution of transduced brain cells following delivery of AAV vectors into the cerebrospinal fluid (CSF) of the cisterna magna (CM) has been demonstrated in large animal brains. In humans, intraventricular injection is preferred to intracisternal injection for CSF delivery due to the risk of brain stem injury. One study in the dog reported adverse reactions to AAV vectors expressing GFP injected into the lateral ventricle but not when injected into the CM.

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