Publications by authors named "P H M Hoet"
Systemic sclerosis (SSc) is an autoimmune chronic connective tissue disorder with a complex pathogenesis and a strong gene-environment interaction. Despite the low prevalence of SSc, with around 100-250 cases per million, the morbidity and mortality are high and disproportionately affecting women. In this context, we review the influence of the external and internal exposome on the "immunome" in SSc.
View Article and Find Full Text PDFArticle Synopsis
- Rising plastic use has led to microplastic contamination, and Raman spectroscopy is a key method for identifying these particles, though it struggles with interference from pigments and additives in colored samples.
- This study evaluates how effective various oxidative treatments (like HO, sodium hypochlorite, and Fenton's reagent) are at reducing these interferences and improving the accuracy of Raman spectroscopy in identifying colored microplastics.
- Findings indicate that colorants, especially red pigments, can significantly hinder polymer identification, and current treatment methods do not effectively enhance accuracy; thus, improved strategies and technology are needed for better results.
Cytotoxicity assessment of eluates from vacuum-forming thermoplastics.
Clin Oral Investig
October 2024
Objectives: This study aimed to evaluate possible cytotoxic effects of thermoplastic materials commonly used for occlusal splints and orthodontic appliances.
Methods: Seven thermoplastics were included: three variants of the Essix sheets (C+, Plus, and Tray Rite; Dentsply Sirona), three thermoplastics (Bleach Heavy, Splint, and X-Heavy; Cavex Holland) and Invisalign (Align Technology). Cylindrical specimens (n = 24; 10 mm diameter) were incubated in cell culture medium for 24 h and 14 days.
Adverse Outcome Pathways (AOPs) have been proposed to facilitate mechanistic understanding of interactions of chemicals/materials with biological systems. Each AOP starts with a molecular initiating event (MIE) and possibly ends with adverse outcome(s) (AOs) via a series of key events (KEs). So far, the interaction of engineered nanomaterials (ENMs) with biomolecules, biomembranes, cells, and biological structures, in general, is not yet fully elucidated.
View Article and Find Full Text PDFBackground: Inhalation of airborne particulate matter, such as silica and diesel exhaust particles, poses serious long-term respiratory and systemic health risks. Silica exposure can lead to silicosis and systemic autoimmune diseases, while DEP exposure is linked to asthma and cancer. Combined exposure to silica and DEP, common in mining, may have more severe effects.
View Article and Find Full Text PDF