Publications by authors named "P H Lowe"
The fluorinase enzyme (EC 2.5.1.
View Article and Find Full Text PDFBackground: Among the many methodological approaches used to generate new knowledge in nursing research are mixed methods and grounded theory. However, it can be challenging for researchers to achieve and demonstrate the philosophically congruent integration required in mixed-method, grounded-theory research.
Aim: To use a hybrid of Delphi and nominal group techniques to develop a tool to appraise the quality of mixed-method, grounded-theory research.
Article Synopsis
- - Clonal hematopoiesis (CH) is the increase of specific blood stem cell clones due to genetic mutations, linked to serious health issues like cancers and cardiovascular diseases, which raise mortality risk.
- - Lymphoid clonal hematopoiesis (L-CH) affects a wider range of genes but is less common and harder to detect compared to its myeloid counterparts.
- - The study presents a targeted sequencing method for accurately identifying CH in bone marrow or blood samples, emphasizing DNA isolation, library preparation, and computational analysis for reliable variant detection.
Article Synopsis
- The study investigates patterns of biologic-switching in dermatology patients at two tertiary hospitals in Australia, focusing on treatment outcomes and factors influencing these switches.
- Data from April 2006 to December 2020 shows that Ustekinumab and Adalimumab were the most common first-line biologics, with a notable 63.8% switching rate among those on TNF-α inhibitors.
- IL-17 inhibitors were found to provide the fastest treatment response and better outcomes, leading to an overall preference for newer biologics over TNF-α inhibitors in recent years.
Sulfur based deoxyfluorination reagents are usually derived from the corrosive gas SF. Herein, we report the synthesis and properties of an easily accessible phosphonium salt [(tmg)PF]SF (1) which was obtained from the reaction of sulfur hexafluoride (SF) with tris(tetramethylguanidinyl)phosphine. The performance of this crystalline SF salt as a reagent in deoxyfluorination reactions was investigated together with a second SF salt [(R)PF]SF (2) containing bulky substituents (R=1,3-di-tert-butylimidazolidin-2-ylidenamino).
View Article and Find Full Text PDF